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. 2023 Jul 14;14:1197648. doi: 10.3389/fendo.2023.1197648

Table 5.

Associations between inflammatory and OS biomarkers and metabolic conditions related parameters.

Model 11 Model 22 Model 33
Beta ± SE P Beta ± SE P Beta ± SE P
Log IL-6
BMI (kg/m2)4 0.016 ± 0.005 0.001 0.015 ± 0.005 0.002 0.012 ± 0.004 0.005
VFL4 0.015 ± 0.007 0.029 0.023 ± 0.007 0.002 0.023 ± 0.007 0.002
RSES -0.023 ± 0.007 0.001 -0.019 ± 0.008 0.014 -0.019 ± 0.008 0.019
Log TNF-α
CESD-R 0.002 ± 0.001 0.055 0.003 ± 0.001 0.050 0.003 ± 0.001 0.015
Log Leptin
BMI (kg/m2)4 0.023 ± 0.006 <0.001 0.017 ± 0.005 <0.001 0.013 ± 0.005 0.008
Body fat (%)4 0.036 ± 0.004 <0.001 0.028 ± 0.005 <0.001 0.025 ± 0.006 <0.001
Log adiponectin
SGPT (iu/l) -0.014 ± 0.003 <0.001 -0.012 ± 0.003 0.001 -0.010 ± 0.004 0.013
Log oxLDL
ΤC (mg/dl) 0.002 ± 0.000 <0.001 0.003 ± 0.000 <0.001 0.003 ± 0.000 <0.001
LDL (mg/dl) 0.002 ± 0.000 <0.001 0.003 ± 0.000 <0.001 0.003 ± 0.000 <0.001
Log oxLDL/HDL
Insulin (μIU/mL) 0.007 ± 0.003 0.007 0.006 ± 0.003 0.015 0.006 ± 0.003 0.040
ΤC (mg/dl) 0.002 ± 0.001 0.001 0.002 ± 0.000 <0.001 0.002 ± 0.001 <0.001
TG (mg/dl) 0.001 ± 0.000 <0.001 0.001 ± 0.000 <0.001 0.001 ± 0.000 <0.001
HDL (mg/dl) -0.378 ± 0.059 <0.001 -0.362 ± 0.068 <0.001 -0.358 ± 0.075 <0.001
LDL (mg/dl) 0.078 ± 0.021 <0.001 0.101 ± 0.020 <0.001 0.104 ± 0.021 <0.001
Log CRP
BMI (kg/m2)4 0.030 ± 0.006 <0.001 0.026 ± 0.006 <0.001 0.025 ± 0.006 0.008
WC (cm)4 0.007 ± 0.003 <0.001 0.011 ± 0.003 <0.001 0.011 ± 0.003 <0.001
Body fat (%)4 0.022 ± 0.005 0.012 0.025 ± 0.007 <0.001 0.021 ± 0.008 <0.001
ALP (U/L) 0.007 ± 0.002 0.003 0.005 ± 0.002 0.013 0.005 ± 0.002 0.036

IL-6, interleukin-6; BMI, body mass index; VFL, visceral fat level; RSES, Rosenberg Self-Esteem scale; Revised; TNF-α, tumor necrosis factor-α; CESD-R, Center for Epidemiologic Studies Depression Scale; SGPT, serum glutamic-pyruvic transaminase; oxLDL, oxidized low-density lipoprotein; TC, total cholesterol; LDL, low-density lipoprotein; HDL, high density lipoprotein; TG, triglycerides; CRP, C-reactive protein; WC, waist circumference; ALP, alkaline phosphatase;

1unadjusted model, 2adjusted for age, gender and WC, 3adjusted for age, gender, WC, physical activity level, smoking and the presence of any of the metabolic disorders (hypertension, hyperglycemia, hyperlipidemia). 4In this analysis, WC was not included as covariate in any model. Values resulted from linear regression models. Level of significance was set as 0.05. Significant p are in bold.