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. 2023 Jun 29;8(8):1534–1548. doi: 10.1038/s41564-023-01418-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a Enrichment plots of chemokine signaling pathway and heatmap of differentially expressed pro-inflammatory genes. b Enrichment plot of triacylglyceride synthesis and heatmap of differentially expressed triacylglyceride synthesis genes. a,b, 5 mice were used in each group. P value obtained with gene set enrichment analysis. c The overall summary of this study. The supplementation of inulin in mouse NASH models lead to the enrichment of P. distasonis and pentadecanoic acid, which restores gut barrier function and downregulated NASH related regulatory pathway (Created with BioRender.com).