Fig. 1.

An overview of simple spatial correlation analyses. First, conventional fMRI results as well as molecular information relating to receptor systems or genes of interest from PET and/or the AHBA are parcellated using an anatomical or functional atlas, producing summary statistics of receptor binding, fMRI connectivity/activation, and AHBA gene expression (shown from top-to-bottom) within each region of the chosen parcellation. Relationships between these vectors can then be explored, typically with Pearson’s correlation coefficient, to quantify how related the patterns of fMRI connectivity/activation are to the receptor density estimates from PET (top) and/or gene expression from the AHBA (bottom).