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. 2023 Jun 9;28(8):965–974. doi: 10.1007/s10147-023-02337-7

Fig. 3.

Fig. 3

The natural history of HPV-associated cervical lesions. A Bidirectional transition of cervical intraepithelial neoplasia (CIN). The natural history of CIN shows a bidirectional transition between different states (normal, CIN1, CIN2, and CIN3). B HPV-genotype-specific characteristics of cervical cancer development. HPV16-related lesion is characterized by stepwise progression to CIN3 or higher, whereas HPV52 and HPV58-related lesions are characterized by their persistency between CIN1 and CIN2. HPV18 is frequently detected in rate in cervical cancer, but its detection rate in precancerous lesions is low. HPV human papillomavirus, CIN cervical intraepithelial neoplasia