Table 2.

Causal associations of PUFAs with the risk of sepsis

Exposures	Methods	No. of SNP	OR	95% CI	P value
Omega-3	MR-Egger	47	0.939	0.842–1.048	0.268
	Weighted median	47	0.931	0.860–1.009	0.082
	Inverse variance weighted	47	0.914	0.845–0.987	0.023
	Simple mode	47	0.868	0.691–1.090	0.229
	Weighted mode	47	0.921	0.858–0.989	0.028
Omega-6	MR-Egger	50	0.828	0.668–1.027	0.092
	Weighted median	50	0.893	0.776–1.027	0.113
	Inverse variance weighted	50	0.920	0.825–1.025	0.131
	Simple mode	50	1.224	0.903–1.659	0.200
	Weighted mode	50	0.830	0.670–1.027	0.092
Ratio of omega-6:3	MR-Egger	34	1.019	0.919–1.129	0.727
	Weighted median	34	1.064	0.991–1.144	0.089
	Inverse variance weighted	34	1.075	0.993–1.164	0.073
	Simple mode	34	1.063	0.843–1.340	0.609
	Weighted mode	34	1.071	0.995–1.153	0.078
DHA	MR-Egger	39	0.945	0.830–1.076	0.399
	Weighted median	39	0.920	0.840–1.008	0.075
	Inverse variance weighted	39	0.893	0.815–0.979	0.015
	Simple mode	39	0.917	0.703–1.196	0.527
	Weighted mode	39	0.905	0.826–0.992	0.040
LA	MR-Egger	43	0.867	0.694–1.082	0.214
	Weighted median	43	0.988	0.848–1.150	0.875
	Inverse variance weighted	43	0.966	0.870–1.072	0.515
	Simple mode	43	1.181	0.844–1.653	0.337
	Weighted mode	43	0.933	0.725–1.200	0.592

PUFAs polyunsaturated fatty acids, DHA docosahexaenoic acid, LA linoleic acid, OR odd ratio, CI confidence interval, MR Mendelian randomization