Table 3.

Causal associations of PUFAs with the risk of sepsis mortality at 28 days

Exposures	Methods	No. of SNPs	OR	Low-CI	Up-CI	P value
Omega-3
	MR Egger	47	0.758	0.609	0.943	0.017
	Weighted median	47	0.787	0.651	0.952	0.014
	Inverse variance weighted	47	0.887	0.755	1.042	0.144
	Simple mode	47	0.800	0.498	1.287	0.362
	Weighted mode	47	0.800	0.667	0.959	0.020
Omega-6
	MR Egger	50	0.891	0.562	1.411	0.625
	Weighted median	50	0.911	0.655	1.266	0.577
	Inverse variance weighted	50	0.973	0.773	1.225	0.815
	Simple mode	50	0.962	0.526	1.761	0.900
	Weighted mode	50	0.880	0.557	1.389	0.584
The ratio of omega-6:3
	MR Egger	34	1.266	1.034	1.549	0.029
	Weighted median	34	1.242	1.036	1.489	0.019
	Inverse variance weighted	34	1.177	1.011	1.371	0.036
	Simple mode	34	1.585	0.850	2.955	0.157
	Weighted mode	34	1.242	1.043	1.479	0.021
DHA
	MR Egger	39	0.751	0.576	0.978	0.040
	Weighted median	39	0.756	0.611	0.935	0.010
	Inverse variance weighted	39	0.819	0.681	0.986	0.035
	Simple mode	39	0.623	0.288	1.348	0.237
	Weighted mode	39	0.762	0.611	0.949	0.020
LA
	MR Egger	43	0.940	0.573	1.541	0.808
	Weighted median	43	1.174	0.836	1.649	0.354
	Inverse variance weighted	43	1.151	0.913	1.453	0.234
	Simple mode	43	1.200	0.635	2.268	0.577
	Weighted mode	43	1.135	0.689	1.868	0.622

PUFAs polyunsaturated fatty acids, DHA docosahexaenoic acid, LA linoleic acid, OR odd ratio, CI confidence interval, MR Mendelian randomization