Table 1.
Weight cohort (n) | BAM dose | Geometric mean, µg/ml (CV%) | ETE dose | Geometric mean, µg/ml (CV%) |
---|---|---|---|---|
Adults ≥ 18 years of agea | 700 mg | 25.7 (42.9) | 1400 mg | 116 (38.1) |
≥ 40 kg (n = 65b) | 700 mg | 29.9 (54.4%) | 1400 mg | 140 (44.0%) |
> 20 kg to < 40 kg (n = 18) | 350 mg | 23.7 (45.6%) | 700 mg | 129 (36.7%) |
> 12 kg to ≤ 20 kg (n = 10) | 175 mg | 21.2 (74.0%) | 350 mg | 122 (57.3%) |
≥ 1.5 kg to ≤ 12 kg (n = 3) | 15 mg/kg | 40.2 (23.2%) | 30 mg/kg | 193 (11.0%) |
BAM bamlanivimab, ETE etesevimab, CV% coefficient of variation as percent
an = 311 in observed BAM serum concentrations and n = 320 in observed ETE serum concentrations
bn = 64 in observed BAM serum concentrations