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. 2023 Jul 31;13:12395. doi: 10.1038/s41598-023-38904-1

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Study design with on the x-axis the time and on the y-axis the degree of headache. Blood sampling (marked by red arrows) was performed at four time points: (A) during migraine attack, (B) 2 h after treatment, (C) at a headache-free day and (D) after a cold-pressor test. Figure previously published by Kogelman et al.⁷.