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. 2023 Jul 31;14:4494. doi: 10.1038/s41467-023-40201-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The Pla2g6^+/+ and Pla2g6^–/– mice were subjected to transverse aortic constriction (TAC) and then analyzed 5 days after the operation. a Representative images of immunohistochemical analysis of CD45, CD68, Ly6G/6C and CD3. Scale bar, 100 μm. The graphs show quantitative analysis of each infiltrating inflammatory cell type (n = 5, biologically independent samples. Sham Pla2g6^+/+ versus TAC Pla2g6^+/+ in CD45-positive cells/LV area P = 0.00007). LV area, left ventricular area. b Expression levels of mRNAs related to inflammatory responses. The levels of mRNA were analyzed 5 days after the operation (n = 6, biologically independent samples). Data were normalized to the Gapdh content and are expressed as the fold increase over the levels in the sham-operated Pla2g6^+/+ group. Open and closed bars indicate Pla2g6^+/+ and Pla2g6^−/−, respectively. Data are expressed as the mean ± SEM. The data were evaluated by one-way ANOVA, followed by Tukey-Kramer’s post-hoc test. Source data are provided as a Source Data file.