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. 2023 Aug 1;14(8):488. doi: 10.1038/s41419-023-06009-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Western blotting of HK2 in radio-sensitive and radio-resistant HCC cells at indicated time point upon 6 Gy radiation. B mRNA expression of HK2 obtained from GEO databases GSE14520 (normal group contains 220 samples and tumor group contains 225 samples), GSE36376 (normal group contains 193 samples and tumor group contains 240 samples). C The overall survival and recurrence-free survival comparison of HCC patients exhibiting high or low HK2 in GSE14520 using Kaplan–Meier analysis (each group contains 110 samples). D Western blotting of HK2 in 12 pairs of HCC tissues, GAPDH was loaded as a control. E Representative images of HK2 staining on tissue microarray (TMA). Scale bar 100 μm. F The overall survival rate of HCC patients according to high or low HK2 protein expression on TMA (HK2-high group contains 39 samples and HK2-low group contains 54 samples). G, H Univariant and multivariant analysis for the prognosis of HCC based on TMA analysis.