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. 2023 Aug 1;14(8):488. doi: 10.1038/s41419-023-06009-2

Fig. 3. HK2’ s role of radio-resistance in vivo.

Fig. 3

A Subcutaneous xenograft nude mice model to twice 8 Gy radiation responsiveness among human HCC cells with different HK2 status in MHCC97L, MHCC97L IR-R. Tumor growth curves and images upon necropsy were presented. Error bars are the SEM of at least five independent replicates. B Representative IHC staining of Ki-67 and HK2 in the formalin-fixed tumor sections from blank and IR groups. Scale bar 20 μm. C Subcutaneous xenograft nude mice model to exhibit radiation responsiveness among mouse HCC cells with different HK2 status. Tumor growth curves and images upon necropsy were presented (n = 5). D Representative IHC staining of PCNA and HK2 in the formalin-fixed tumor sections from indicated treatment groups. Scale bar 20 μm. E Subcutaneous xenograft model in C57BL/6 mice to twice 8 Gy radiation responsiveness among H22 cells with different HK2 status. Tumor volumes were presented (n = 8). F Representative IHC staining of PCNA, CD8, CD163, and HK2 in the formalin-fixed tumor sections from indicated treatment groups. Scale bar 40 μm. Data were represented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.