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. 2023 Jul 31;13:12344. doi: 10.1038/s41598-023-39499-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Circumferential diastolic strain rate is reduced in T2D mice. (A,B) Circumferential diastolic and systolic peak strain rate, acquired in the short axis imaging plane. Analyzed by Students unpaired t-test. (C,D) Circumferential diastolic and systolic peak velocity, acquired in the short axis imaging plane. Analyzed by Students unpaired t-test. (E) Schematic of short axis view left ventricle segmentation for regional strain analysis. (F) Regional circumferential peak strain rate. Analyzed by 1-way repeated measures ANOVA, annotated with LSD post hoc analyses. P = 0.07 T2D factor effect. (G) Regional circumferential peak velocity. Analyzed by 1-way repeated measures ANOVA, annotated with LSD post hoc analyses. Data are presented as mean ± SEM. n = 7–8/group. *p < 0.05. RV right ventricle, AFW anterior free wall, LW lateral wall, PW posterior wall, IFW inferior free wall, PSW posterior septal wall, AS anterior septum.