TABLE 1.
Standardized assessment performed before and during the treatment.
| Standardized assessment | Age (months) | |||||||
|---|---|---|---|---|---|---|---|---|
| Before therapy | During therapy | |||||||
| 16 | 22 | 28 | 36 | 38 | 39 | 45 | 53 | |
| GMFM‐88 domain, % | ||||||||
| Lying & rolling | 92 | 47 | 47 | 55 | 55 | 57 | 57 | 60 |
| Sitting | 70 | 25 | 25 | 30 | 35 | 35 | 35 | 38 |
| Crawling & kneeling | 69 | 0 | 0 | 5 | 5 | 5 | 5 | 5 |
| Standing | 44 | 0 | 0 | 5 | 5 | 10 | 10 | 10 |
| Walking, running & jumping | 21 | 0 | 0 | 1 | 1 | 1 | 1 | 1 |
| Total score | 59 | 15 | 15 | 19 | 20 | 22 | 22 | 23 |
| Griffiths‐III, standard score | ||||||||
| Foundation of learning | 74 | <50 | <50 | 74 | – | – | 102 | 105 |
| Language and communication | 91 | <50 | <50 | 57 | – | – | 94 | 109 |
| Hand‐eye coordination | 79 | <50 | <50 | <50 | – | – | 61 | 64 |
| Personal‐social‐emotional | 102 | <50 | <50 | 66 | – | – | 90 | 104 |
| Gross‐motor | 95 | <50 | <50 | <50 | – | – | <50 | <50 |
| Total score | 87 | <50 | <50 | <50 | – | – | 55 | 61 |
| AGS severity scale | – | 5 | 6 | 6 | 7 | 9 | 9 | 9 |
| VABS‐II, p | ||||||||
| Communication skills | – | – | – | 4 | – | – | 6 | 68 |
| Daily living skills | – | – | – | 1 | – | – | 2 | 70 |
| Socialization | – | – | – | 14 | – | – | 68 | 93 |
| Motor skills | – | – | – | 0.5 | – | – | <0.1 | <0.1 |
| Total score | – | – | – | 16 | – | – | 3 | 39 |
Abbreviations: AGS, Aicardì‐Goutieres syndrome; GMFM‐88, Gross Motor Function Measure‐88; Griffiths‐III, Griffiths Mental Development Scales‐III; VABS‐II, Vineland Adaptive Behavior Scale‐II.