Table 5.
Anticancer Effects of Biosynthesized NiO Nanoparticles
| Types of Cells/Cell Lines | NiO NPs | Method | Toxicity (IC50) (µg/mL) | Ref. | ||
|---|---|---|---|---|---|---|
| Size (nm) | Shape | |||||
| Breast cancer | ||||||
| MCF-7 | 32 | Cube | MTT assay | 55 | [126] | |
| 24 | Cube | MTT assay | 44.91 | [38] | ||
| Cervical cancer | ||||||
| HeLa | – | Cube | MTT assay | 120 | [84] | |
| Liver cancer | ||||||
| HepG2 | 21 | Spherical | MTT assay | 37.84 | [36] | |
| 12–15 | Rhombohedra | MTT assay | 344.26 | [40] | ||
| 24 | Spherical | MTT assay | 29.68 | [35] | ||
| 25 | Spherical | MTT assay | 20.73 | [42] | ||
| HuH7 | 25 | Spherical | MTT assay | 11.3 | [42] | |
| Lung cancer | ||||||
| A549 | 12–15 | Rhombohedra | MTT assay | 353.16 | [40] | |
| 5–15 | Hexagonal and rhombohedral | MTT assay | 93.35 | [130] | ||
| Glioblastoma cancer | ||||||
| U87MG | – | Cube | MTT assay | 15.62 | [112] | |
| 18–43 | Sheet, plate, cube | MTT assay | 125 | [131] | ||
| 59 | Spherical | MTT assay | 37.84 | [110] | ||
| Esophageal | ||||||
| FLO-1 | 60.39 | Spherical | MTT assay | 380 | [132] | |
| ESO26 | 60.39 | Spherical | MTT assay | 263 | [132] | |
| OE33 | 60.39 | Spherical | MTT assay | 229 | [132] | |
| KYSE-270KYSE-270 | 60.39 | Spherical | MTT assay | 251 | [132] | |