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. 2023 Jul 18;14:1220028. doi: 10.3389/fimmu.2023.1220028

Figure 2.

Figure 2

Whole blood collected during MODS revealed significantly increased mRNA expression of nine genes associated with neutrophil degranulation in pediatric patients who had Prolonged MODS or Died (n=38) compared to patients that Recovered from MODS (n=27). Never MODS was included as an influenza positive PICU control (n=126). After adjustment for multiple comparisons, transcription levels between Recovered vs Never MODS did not have any statistically differences. Note the different y-axis for H and I. ****q<0.0001, ***q ≤ 0.001, **q ≤ 0.01, *q<0.05. All Tukey box plots represent the median (center line of the box), 25% IQR (Q1, bottom line of the box), 75% IQR (Q3, top line of the box), error bars are the minimum and maximum values within 1.5x the Q1 and Q3 quadrants, outliers indicated by circles. MODS, Multiple Organ Dysfunction Syndrome. (A) RETN, Resistin. (B) TCN1, Haptocorin. (C) OLFM4, Olfactomedin 4. (D) LCN2, Lipocalin 2. (E) BPI, Bactericidal Permeability Increasing Protein. (F) MMP8, Matrix Metallopeptidase 8. (G) LTF, Lactotransferrin. (H) S100A12, S100 Calcium Binding Protein A12. (I) GUSB, Glucuronidase Beta.