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Biomarkers currently with drugs that have FDA approval for a tissue agnostic indication.
| Biomarker/target | Approved drug(s) | Year of FDA approval |
|---|---|---|
| dMMR | Pembrolizumab | 2017 |
| Dostarlimab | 2022 | |
| MSI-H | Pembrolizumab | 2017 |
| TMB-High | Pembrolizumab | 2020 |
| BRAF V600E | Dabrafenib + Trametinib | 2022 |
| RET fusions | Selpercatinib | 2022 |
| NTRK fusions | Larotrectinib | 2018 |
| Entrectinib | 2019 |
