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. 2023 Jun 26;42(15):e111247. doi: 10.15252/embj.2022111247

Figure 1. Deletion of astroglial CD38 in postnatal brain impairs social memory.

Figure 1

  • A–I
    (A, F) Paradigm for inducing astrocyte‐specific deletion of CD38 from P10 in ctrlP10 and CD38 AS‐cKOP10 mice (A) or from P42 in ctrlP42 and CD38 AS‐cKOP42 mice (F) and behavior tests. (B) Schematic diagram of social behavior tests in the three chamber test. (C, G) Sociability of ctrlP10 and CD38 AS‐cKOP10 mice (C) or ctrlP42 and CD38 AS‐cKOP42 (G) mice (n = 7–10 animals per genotype). (D, H) Social novelty of ctrlP10 and CD38 AS‐cKOP10 mice (D) or ctrlP42 and CD38 AS‐cKOP42 (H) mice (n = 7–10 animals per genotype). (E, I) Social memory of ctrlP10 and CD38 AS‐cKOP10 mice (E) or ctrlP42 and CD38 AS‐cKOP42 (I) mice (n = 7–10 animals per genotype).

Data information: Data represent means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 (two‐way ANOVA followed by Bonferroni's multiple comparisons test).