TABLE 4.
Association of MAT Initiation Year with Relapse Rate Within 6 Months After MAT Initiation
| Variable | Odds ratio (95% CI) | P value |
|---|---|---|
| Year of MAT initiation | ||
| 2017 | (Reference) | – |
| 2018 | 0.813 (0.684-0.967) | 0.02 |
| Age at time of initiation | ||
| 19-54 years | (Reference) | – |
| 55-64 years | 0.922 (0.754-1.127) | 0.30 |
| 65-89 years | 1.021 (0.806-1.293) | 0.56 |
| Sex | ||
| Male | (Reference) | – |
| Female | 1.171 (0.985-1.393) | 0.07 |
| Population density at time of initiation | ||
| Urban | (Reference) | – |
| Suburban | 1.002 (0.819-1.225) | 0.32 |
| Rural | 0.896 (0.687-1.169) | 0.08 |
| Unknown | 1.671 (0.943-2.962) | 0.06 |
| 1-unit increase in Elixhauser scorea | 1.073 (1.038-1.11) | < 0.001 |
| OUD diagnosisa | ||
| No | (Reference) | – |
| Yes | 0.530 (0.432-0.651) | < 0.001 |
| Mental or behavioral health diagnosisa | ||
| No | (Reference) | – |
| Yes | 0.919 (0.665-1.269) | 0.61 |
| LIS/dual eligibility status at time of initiation | ||
| No LIS or dual eligibility | (Reference) | – |
| LIS or dual eligibility | 0.961 (0.802-1.152) | 0.67 |
| Opioid dosage (daily MED) at time of initiation | ||
| ≤ 49 mg | (Reference) | – |
| 50-89 mg | 0.866 (0.700-1.072) | 0.23 |
| 90-149 mg | 0.870 (0.67-1.129) | 0.34 |
| ≥ 150 mg | 1.105 (0.835-1.461) | 0.16 |
| ≥ 1 inpatient admissiona | ||
| No | (Reference) | – |
| Yes | 1.076 (0.854-1.356) | 0.54 |
| ≥ 1 ED visita | ||
| No | (Reference) | – |
| Yes | 1.159 (0.952-1.411) | 0.14 |
Notes: Authors’ analysis of claims data is presented for individuals (aged 19-89 years) participating in a Humana MAPD plan in 2017 and/or 2018 who could be identified as opioid users and recipients of MAT for OUD. Analysis excludes individuals without continuous enrollment from 6 months before and after MAT initiation. Odds ratios were generated with logistic regression models.
a According to claims from the 6-month period before MAT initiation.
ED = emergency department; LIS = low-income subsidy; MAPD = Medicare Advantage and Prescription Drug plan; MAT = medication-assisted therapy; MED = morphine equivalent dose; OUD = opioid use disorder.