TABLE 1.

Baseline Characteristics of Unmatched and Propensity Score-Matched Cohorts

Baseline Characteristics	Unmatched Cohorts (n = 19,614)			Propensity Matched Cohorts (n = 3,766)
	Nonusers n=17,525	Users n=2,089	P Value	Nonusers n=1,883	Users n=1,883	P Value
Age in years, mean	50.41	60.77	< 0.001	60.78	60.14	0.111
Gender, %
Female	76.37	64.29	< 0.001	66.91	65.91	0.512
Male	23.63	35.71		33.29	34.09
BMI, mean	25.28	27.88	< 0.001	27.28	27.53	0.300
Comorbidities, %
AIDS/HIV	0.34	0.29	0.710	0.32	0.27	0.763
Nonmetastatic malignancy	8.48	9.29	0.213	9.77	9.24	0.578
Cerebrovascular disease	5.65	11.63	< 0.001	10.04	9.88	0.870
Chronic pulmonary disease	17.73	19.34	0.071	20.13	18.37	0.173
Congestive heart failure	3.71	9.24	< 0.001	7.97	7.33	0.462
Dementia	0.55	1.20	< 0.001	1.22	0.90	0.340
Diabetes without complications	5.72	15.03	< 0.001	13.49	12.59	0.411
Diabetes with complications	3.13	8.28	< 0.001	7.33	7.43	0.901
Hemiplegia or paraplegia	1.91	2.68	0.016	1.86	2.39	0.258
Metastatic solid tumor malignancy	3.11	2.78	0.404	2.50	2.81	0.543
Liver disease	9.64	9.53	0.864	10.04	9.24	0.408
Myocardial infarction	1.56	7.28	< 0.001	5.26	4.78	0.502
Peptic ulcer disease	3.51	3.83	0.463	4.20	3.72	0.452
Peripheral vascular disease	4.11	10.72	< 0.001	9.51	8.87	0.498
Renal disease	4.48	9.86	< 0.001	8.71	8.44	0.771
Rheumatic disease	17.21	21.21	< 0.001	19.86	20.07	0.870
Medication use, %
Antihypertensive drugs	13.86	51.80	< 0.001	46.20	47.37	0.472
Diuretics	9.23	32.31	< 0.001	29.21	29.05	0.914
Glucocorticoids	26.84	40.88	< 0.001	41.74	39.88	0.246
Anticoagulants	4.95	14.70	< 0.001	12.69	13.01	0.770
Insulin	5.27	24.70	< 0.001	19.86	19.76	0.935
Nitrates	1.52	11.68	< 0.001	7.65	7.65	1.000
DMARDs	4.79	3.54	0.010	3.03	3.56	0.361
NSAIDs	27.49	36.14	< 0.001	37.12	36.06	0.499

BMI = body mass index; DMARD = disease-modifying antirheumatic drug; NSAID = nonsteroidal anti-inflammatory drug.