TABLE 2.
Unadjusted and Adjusted Odds Ratios for Mortality Associated with Statin Use
| Variables | Unadjusted Regression | Adjusted Regression | ||||
|---|---|---|---|---|---|---|
| Odds Ratio | 95% CI | P Value | Odds Ratio | 95% CI | P Value | |
| Age | 1.03 | (1.02-1.05) | < 0.001 | 1.03 | (1.01-1.05) | < 0.001 |
| Gender | 1.37 | (0.96-1.95) | 0.074 | 1.13 | (0.78-1.65) | 0.502 |
| BMI | 0.97 | (0.95-1.00) | 0.066 | 0.97 | (0.95-1.00) | 0.120 |
| AIDS/HIV | 2.70 | (0.34-21.26) | 0.345 | 1.44 | (0.15-13.48) | 0.744 |
| Nonmetastatic malignancy | 1.48 | (0.89-2.47) | 0.125 | 1.11 | (0.64-1.92) | 0.702 |
| Cerebrovascular disease | 0.96 | (0.53-1.72) | 0.897 | 0.49 | (0.25-0.96) | 0.037 |
| Chronic pulmonary disease | 2.16 | (1.50-3.13) | < 0.001 | 1.53 | (0.99-2.36) | 0.051 |
| Congestive heart failure | 2.32 | (1.43-3.75) | 0.001 | 1.23 | (0.68-2.21) | 0.478 |
| Dementia | 3.95 | (1.52-10.25) | 0.005 | 2.26 | (0.79-6.50) | 0.128 |
| Diabetes without complications | 1.09 | (0.66-1.79) | 0.716 | 0.64 | (0.36-1.12) | 0.122 |
| Diabetes with complications | 1.35 | (0.75-2.43) | 0.311 | 0.53 | (0.26-1.06) | 0.075 |
| Hemiplegia or paraplegia | 1.42 | (0.51-3.96) | 0.494 | 1.43 | (0.47-4.33) | 0.517 |
| Metastatic solid tumor malignancy | 6.15 | (3.54-10.70) | < 0.001 | 3.96 | (2.12-7.37) | < 0.001 |
| Liver disease | 2.70 | (1.76-4.13) | < 0.001 | 2.16 | (1.32-3.55) | < 0.001 |
| Myocardial infarction | 1.54 | (0.79-2.98) | 0.199 | 0.93 | (0.44-1.95) | 0.854 |
| Peptic ulcer disease | 1.78 | (0.88-3.57) | 0.105 | 1.03 | (0.47-2.24) | 0.924 |
| Peripheral vascular disease | 1.87 | (1.16-3.02) | 0.010 | 0.91 | (0.52-1.61) | 0.769 |
| Renal disease | 2.28 | (1.43-3.62) | < 0.001 | 1.45 | (0.83-2.52) | 0.184 |
| Rheumatic disease | 1.99 | (1.38-2.88) | < 0.001 | 1.22 | (0.81-1.84) | 0.338 |
| Antihypertensive drugs | 2.04 | (1.43-2.92) | < 0.001 | 1.25 | (0.84-1.87) | 0.263 |
| Diuretics | 2.48 | (1.76-3.51) | < 0.001 | 1.59 | (1.07-2.38) | 0.022 |
| Glucocorticoids | 1.63 | (1.16-2.31) | 0.005 | 1.20 | (0.82-1.75) | 0.335 |
| Anticoagulants | 1.33 | (0.83-2.13) | 0.225 | 0.86 | (0.51-1.43) | 0.569 |
| Insulin | 3.32 | (2.34-4.72) | < 0.001 | 2.80 | (1.84-4.26) | < 0.001 |
| Nitrates | 2.32 | (1.43-3.75) | 0.001 | 1.60 | (0.94-2.74) | 0.080 |
| DMARDs | 0.43 | (0.10-1.76) | 0.243 | 0.70 | (0.16-2.93) | 0.627 |
| NSAIDs | 0.92 | (0.64-1.32) | 0.663 | 0.88 | (0.60-1.29) | 0.520 |
| Statins | 0.61 | (0.43-0.87) | 0.007 | 0.65 | (0.45-0.94) | 0.023 |
Note: Adjusted for age, gender, BMI, comorbidities, and medication use.
BMI = body mass index; DMARD = disease-modifying antirheumatic drug; NSAID = nonsteroidal anti-inflammatory drug.