TABLE 1.
Drug Acquisition Costsa
| Treatment | Cost per week, 2019 USD | |
|---|---|---|
| Main comparators | ||
| Vedolizumab IV (induction)b | $3,234 | |
| Vedolizumab IV (maintenance)b | $809 | |
| Adalimumab SC (induction)c | $2,587 | |
| Adalimumab SC (maintenance)c | $1,293 | |
| Downstream treatments | ||
| Tofacitinib | $1,034 | |
| Infliximab | $1,167 | |
| Golimumab | $1,499 | |
| Standard of care | ||
| Oral steroids | $25 | |
| Intensive IV steroids | $86 | |
| Immunosuppressive agents: IV cyclosporine | $2,366 | |
| Health care resource utilizationd | Unit frequency | Unit cost, 2019 USD |
| Routine monitoringe | ||
| Outpatient visit for new patient | 1 | $300.09 |
| Outpatient visit for established patient | 13 | $195.71 |
| Endoscopy | 1 | $1,287.17 |
| Lab test: complete blood count | 4 | $10.66 |
| Lab test: liver function test | 4 | $11.21 |
| Lab test: lipid panel | 4 | $17.86 |
| Lab test: antidrug antibody | 4 | $38.16 |
| Drug administration | ||
| Dispensing fee | Per month | $5.42 |
| Vedolizumab IV drug administration | Per infusion | $186.40 |
| ADR | ||
| Major ADR | 1 | $21,896 |
| Minor ADR | 1 | $1,329 |
| Curative surgery (colectomy, average of DRG 329, 330, 331) | 1 | $18,196 |
aResource utilization and costs for drug acquisition, drug administration, inpatient and outpatient visits, and ADR management were derived from publicly available reference sources: the Micromedex database for drug cost information and product labels for dosing and administration information.19 Given the differences in dosing and administration frequency, we applied drug costs on a weekly basis as determined by the annual cost per course divided by 52 weeks.
bVedolizumab 300 mg IV on day 1 and weeks 2 and 6 (induction) and every 8 weeks thereafter (maintenance).
cAdalimumab 160 mg SC on day 1, adalimumab 80 mg SC at week 2, adalimumab 40 mg SC at weeks 4 and 6 (induction), then adalimumab 40 mg SC every 2 weeks thereafter (maintenance).
dCosts of ADRs and other direct medical costs were based on CPT and DRG codes.
eAll patients received initial or subsequent treatment for the entire model horizon; thus, costs of routine monitoring are equal for both treatment arms.
ADR = adverse drug reaction; CPT = Current Procedural Terminology; DRG = diagnosis-related group; IV = intravenous; SC = subcutaneous; USD = US dollars.