TABLE 1.
Survival of rabbits infected with LAT2.9A
| Expt | Virusa | Survival (%)b | P vs LAT2.9Ac |
|---|---|---|---|
| 1 | LAT2.9A | 3/18 (17) | |
| dLAT2903 (LAT−) | 7/18 (39) | 0.26 | |
| LAT3.3A (wt) | 6/18 (33) | 0.44 | |
| dLAT2903R (wt) | 7/18 (39) | 0.26 | |
| 2 | LAT2.9A | 7/22 (32) | |
| dLAT2903R (wt) | 12/22 (55) | 0.22 | |
| 3 | LAT2.9A | 4/16 (25) | |
| LAT2.9AR | 7/16 (44) | 0.46 | |
| dLAT371 (wt) | 7/16 (44) | 0.46 | |
| dLAT371R (wt) | 11/16 (69) | 0.032 | |
| Totalsd | LAT2.9A | 14/56 (25) | |
| dLAT2903 | 34/68 (50) | 0.006 | |
| Wild-type viruses | 50/106 (47) | 0.007 |
a
Viruses designated “(wt)” have previously been shown to be have the same virulence rate based on rabbit survival as the parental McKrae wild-type virus.
b
Rabbits were ocularly infected as described in Materials and Methods. Survival was determined on day 21 postinfection as the number of surviving animals/total rabbits infected with each virus.
c
Fisher exact test. P < 0.05 indicates statistical significance.
d
Wild-type viruses are a compilation of all of the above wild-type viruses plus LAT2.9AR, which appeared to behave like wild type. dLAT2903 data was compiled from experiment 1 and the four most recent experiments in our laboratory that included dLAT2903 as a negative control.