TABLE 1.

Treatment and Procedure Cost Inputs

Cost Item	Inputs	Source/Notes
Pretreatment period: lymphodepleting therapy
Regimen 1	Proportion of patientsa: 94.94%	ELIANA trial10,13
Fludarabine	Drug cost: $281.23 Administration cost: $572.32	RED BOOK17 CMS Physician Fee Schedule18
Cyclophosphamide	Drug cost: $817.47 Administration cost: $138.40	RED BOOK17 CMS Physician Fee Schedule18
Regimen 2	Proportion of patientsa: 1.27%	ELIANA trial10,13
Cytarabine	Drug cost: $11.40 Administration cost: $138.40	RED BOOK17 CMS Physician Fee Schedule18
Etoposide	Drug cost: $42.40 Administration cost: $522.21	RED BOOK17 CMS Physician Fee Schedule18
Infusion period: tisagenlecleucel infusion
Tisagenlecleucel	Drug cost: $475,000 Administration cost: $143.08	RED BOOK17 CMS Physician Fee Schedule18

^a The proportion of patients was estimated based on the observation from the ELIANA trial.

CMS = Centers for Medicare & Medicaid Services.