. Author manuscript; available in PMC: 2023 Aug 1.

Published in final edited form as: Mod Pathol. 2022 Feb 18;35(8):1045–1054. doi: 10.1038/s41379-022-01024-8

Table 2.

Risk profile changes.

		Fraction of patients
	Pack-years	2000–2005	2006–2010	2011–2015
Tobacco exposure	<10	0.2	0.16	0.28
	≥10	0.8	0.84	0.72
	<30	0.36	0.28	0.49
	≥30	0.64	0.72	0.51
	Mean	44.39	45.46	32.16
	Median	40	41.5	30
p16—clinical	Neg	0.68	0.48	0.36
	Pos	0.32	0.52	0.64
p16—research	0–25	0.58	0.41	0.33
(% tumor cells with strong nuclear staining)	25–50	0.03	0.02	0.08
	50–75	0.12	0.03	0.06
	75–100	0.27	0.54	0.53