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. Author manuscript; available in PMC: 2024 May 8.
Published in final edited form as: Cancer Cell. 2023 Apr 20;41(5):970–985.e3. doi: 10.1016/j.ccell.2023.03.018

Figure 6. Individual patient comparisons of matched primary and metastatic samples.

Figure 6.

(A) Summary of genomic and clinical characteristics of patients with one primary and ≥2 matched sequenced metastases. Each numbered cluster represents a patient. One column represents a sequenced sample with the first column representing the primary sample and subsequent columns representing metastatic samples. For example, Patient 1 has one primary and five metastatic samples. (B) Phylogenetic trees for two patients with multiple matched samples, including timeline of sample acquisition and treatment course. CNS, central nervous system; FGA, fraction of genome altered; LN, lymph node; TMB, tumor mutational burden; Tx, treatment; WGD, whole-genome duplication; XRT, radiation.