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. 2022 Nov 15;3(3):244–253. doi: 10.1016/j.jointm.2022.10.001

Table 3.

Non-infectious causes of high fever in patients monitored in the ICU.

High fever (38–41 °C) Hyperthermia (>41 °C)
Drug reaction Drug reaction, such as malignant hyperthermia, neuroleptic malignant syndrome and serotonin syndrome
Venous thromboembolism
Pulmonary embolism
Endocrine, such as thyrotoxicosis, adrenal crisis and Ppeochromocytoma
Central nervous system
Subarachnoid hemorrhage
Environmental heat stroke
Pancreatitis Viral infections, such as COVID-19, SARS, MERS, German measles, influenza, rabies
Systemic lupus erythematosus
Malignancy
Transfusion reactions

COVID-19: Coronavirus disease 2019; ICU: Intensive care unit; MERS: Middle East respiratory syndrome; SARS: Severe acute respiratory syndrome.