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. 2023 Jul 18;25(29):5520–5524. doi: 10.1021/acs.orglett.3c01990

Table 1. Optimization of the Photoinduced Synthesis of β-Lactams.

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entry light source solvent 5 (equiv) yield 6 (%)a
1 440 nm LED ethyl acetate 1.0 78
2 440 nm LED toluene 1.0 90
3 440 nm LED acetonitrile 1.0 51
4 440 nm LED ethyl acetate 1.2 86 (72b, 86c)
5 525 nm LED ethyl acetate 1.2 n.d.
a

Yield determined by 1H NMR using durene as the internal standard;

b

Isolated yield.

c

Conducted on 1 mmol scale.