Skip to main content
. 2023 Jul 7;42(7):112713. doi: 10.1016/j.celrep.2023.112713

Figure 1.

Figure 1

High-fat diet exacerbates psoriatic skin inflammation

C57BL/6 mice were fed a normal diet (2.9% or 3.3% fat content) or high-fat diet (11.3%, 35.7%, or 79.2% fat content) for 7–10 weeks. Mice were topically treated with imiquimod (IMQ) cream on one ear for the last 3 days of the experiment, while the contralateral ear remained unchallenged (n = 5–10 per group).

(A) Ear thickness measured by caliper and quantification of epidermal thickness in histopathology sections shown. Bars show the mean ± SD. p values were calculated by analysis of variance followed by Jonckheere-Terpstra test. Representative H&E staining of IMQ-treated ears are also shown.

(B) Correlation between fat, sugar, and protein contents of the food and ear thickness. Spearman’s rank correlation coefficient (rS) and p values are shown.

(C) Numbers of immune cells in IMQ-challenged and unchallenged contralateral ears of mice fed with normal diet (ND; 3.3% fat) or high-fat diet (HFD; 35.7% fat) (n = 10). Bars show the mean ± SD. p values were calculated by unpaired Student’s t test.