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. 2023 Jul 7;42(7):112713. doi: 10.1016/j.celrep.2023.112713

Figure 6.

Figure 6

Akk suppresses psoriatic skin inflammation and systemic IL-17 induced by HFD

C57BL/6 mice were fed an ND (3.3% fat) or HFD (35.7% fat) for 8 weeks and challenged with IMQ. Oral gavages of live or heat-killed Akk were done for the last 2 weeks.

(A) Representative H&E staining of the IMQ-treated ears from HFD and HFD-live Akk-treated mice.

(B) Ear thickness was quantified in these different groups (n = 8–20).

(C and D) Comparison of the proportion of PMA/ionomycin-stimulated IL-17A+ T cells, γδ T cells, and IL-17+ γδ T cells in mLNs from each group (n = 5–6).

(E and F) Flow cytometric analysis of the IL-17+ T lymphocytes in the spleen. The boxed population shows the proportion of CD3 T cells (E). Proportion (%) of IL-17+ T lymphocytes (F) (n = 5). Data are presented as the mean ± SD. p values were calculated by analysis of variance followed by Sidak’s post hoc tests for comparison of groups indicated.