Male (A, C, E, G) and female (B, D, F, H) mice received vehicle or DHNA, and then were unstressed or subjected to UCMS for 4 weeks. Sucrose preference was monitored weekly starting at the end of the second week of UCMS, and continuing until 1 week post UCMS (A, B). Then mice were examined for FST (C, D), splash test (E, F), and tape groom test (G, H). (*)Bonferroni post hoc contrast indicates a significant difference from unstressed mice (p < 0.05); (§) Bonferroni post hoc contrast indicates a significant difference from DHNA/UCMS (p < 0.05). (ε)Bonferroni post hoc contrast indicates a significant difference from DHNA/NS (p < 0.05). Results are presented as mean + SEM.