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MET overexpression causes resistance to osimertinib, sotorasib, poziotinib, and entrectinib
(A) The indicated tetON-MET cells were induced with doxycycline for 48 h before lysis. Western blot analysis was performed with the indicated antibodies.
(B) Cells were cultured with doxycycline for 24 h before being treated with the respective targeted therapies. Cellular viability was measured six days from treatment onset. Data are represented as mean of n = 3 ± SD.
