REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
rabbit anti-phospho-MET, 1:1000	Cell Signaling	#3077; RRID:AB_2143884
mouse anti-Met, 1:1000	Cell Signaling	#3127; RRID:AB_331361
mouse anti-AKT, 1:1000	Cell Signaling	#2920; RRID:AB_1147620
rabbit anti-phospho-Akt (Ser473), 1:1000	Cell Signaling	#4058; RRID:AB_331168
mouse anti-STAT3, 1:1000	Cell Signaling	#9139; RRID:AB_331757
rabbit anti- phospho-Stat3 (Tyr705) (D3A7) XP, 1:2000	Cell Signaling	#9145; RRID:AB_2491009
rabbit anti-phospho p44/42 MAP Kinase (Erk1/2), 1:1000	Cell Signaling	#9101; RRID:AB_331646
mouse anti-ERK, 1:5000	BD	#610123; RRID:AB_397529
mouse anti-GAPDH, 1:50000	Santa Cruz	#sc-32233; RRID:AB_627679
goat anti-rabbit Alexa Fluor 680, 1:25000	Thermo Fisher	#A21076; RRID:AB_2535736
donkey anti-mouse IRDye 800CW, 1:25000	LI-COR	#926-32212; RRID:AB_621847
MET SP44 clone	Roche, Mannheim, Germany	NA
Chemicals, peptides, and recombinant proteins
alectinib	BOC Sciences	NA
capmatinib	ChemShuttle	NA
entrectinib	Medchemexpress	NA
M6748	The healthcare business of Merck KGaA, Darmstadt, Germany International Patent Application Publication No.: WO2020/033828 A1, Example #10b)	NA
osimertinib	VWR	NA
poziotinib	AChemBlock	NA
sotorasib	Medchemexpress/MedKoo Biosciences	NA
tepotinib	The healthcare business of Merck KGaA, Darmstadt, Germany	NA
TNO155	Synthesized at the healthcare business of Merck KGaA, Darmstadt, Germany	NA
Deposited data
Patient 1	This paper, deposited in NCBI SRA: PRJNA975367	SAMN35325464
Patient 2	This paper, deposited in NCBI SRA: PRJNA975367	SAMN35325465 SAMN35325466
Patient 3	This paper, deposited in NCBI SRA: PRJNA975367	SAMN35325467
Patient 4	This paper, deposited in NCBI SRA: PRJNA975431	SAMN35326201
Patient 5	This paper, deposited in NCBI SRA: PRJNA975431	SAMN35326202
Patient 6	This paper, deposited in NCBI SRA: PRJNA975431	SAMN35326203 SAMN35326204
Patient 7	This paper, deposited in NCBI SRA: PRJNA975431	SAMN35326205
Patient 8	This paper, deposited in NCBI SRA: PRJNA975431	SAMN35326206 SAMN35326207
Patient 9	This paper, deposited in NCBI SRA: PRJNA975431	SAMN35326208
Patient 10	This paper, deposited in NCBI SRA: PRJNA975431	SAMN35326209
Patient 11	This paper, deposited in NCBI SRA: PRJNA975431	SAMN35326210
Patient 12	This paper, deposited in NCBI SRA: PRJNA975444	SAMN35326335
Patient 13	This paper, deposited in NCBI SRA: PRJNA975444	SAMN35326336
Patient 14	This paper, deposited in NCBI SRA: PRJNA975444	SAMN35326337
Patient 15	This paper, deposited in NCBI SRA: PRJNA975444	SAMN35326338
Patient 16	This paper, deposited in NCBI SRA: PRJNA975444	SAMN35326339
Patient 17	This paper, deposited in NCBI SRA: PRJNA975444	SAMN35326340
Patient 18	This paper, deposited in NCBI SRA: PRJNA975444	SAMN35326341
Patient 19	This paper, deposited in NCBI SRA: PRJNA975444	SAMN35326342
Patient 20	This paper, deposited in NCBI SRA: PRJNA975444	SAMN35326343
Patient 22	This paper, deposited in NCBI SRA: PRJNA975361	SAMN35325436 SAMN35325437
Patient 23	This paper, deposited in NCBI SRA: PRJNA975361, PRJNA975444	SAMN35325438 SAMN35326344
Patient 24	This paper, deposited in NCBI SRA: PRJNA975456	SAMN35326492
Patient 25	This paper, deposited in NCBI SRA: PRJNA975361, PRJNA975456	SAMN35325439 SAMN35326493 SAMN35326494
Patient 26	This paper, deposited in NCBI SRA: PRJNA975456	SAMN35326495 SAMN35326496
Patient 27	This paper, deposited in NCBI SRA: PRJNA975456	SAMN35326497 SAMN35326498 SAMN35326499 SAMN35326500 SAMN35326501
Patient 28	This paper, deposited in NCBI SRA: PRJNA975456	SAMN35326502 SAMN35326503
Experimental models: Cell lines
HCC827	ATCC	ATCC CRL-2868
NCI-H358	ATCC	ATCC CRL-5807
NCI-H1781	ATCC	ATCC CRL-5894
KM12	M.D. Anderson Cancer Center	NA
NCI-H2228	ATCC	ATCC CRL-5935
HCC-78	DSMZ	ACC 563
Oligonucleotides
Probe set for nCounter hybridization, refer to Table S2	NanoString Technologies, customized nCounter panel	NA
Recombinant DNA
pcLVi(3G)-MET-EF1a-TetON-T2A-Puro-WPRE	SIRION Biotech GmbH	NA
Software and algorithms
Prism (version 8.2.0)	GraphPad	NA
GeneData Screener® Software (version 16.0.5)	Genedata	NA
nSolver™ (version 2.6)	NanoString Technologies	NA