Figure 7.

HILPDA does not influence HFD-induced metabolic and inflammatory complications. A) Weight of the liver and various adipose tissue depots in Hilpda^flox/flox and Hilpda^ΔADIPO mice fed a low-fat diet (LFD) or high-fat diet (HFD) for 20 weeks (n = 9–12 per group). gWAT, gonadal (epididymal) adipose tissue; iWAT, inguinal adipose tissue; BAT, brown adipose tissue. B) Plasma concentration of glucose, glycerol, triglycerides, cholesterol, and NEFA. C) Plasma levels of metabolism-related hormones. D) Liver triglyceride content (%, wt/wt). E) Intraperitoneal glucose tolerance test and Area Under the Curve. F) Relative mRNA expression of inflammation-related genes in epididymal white adipose tissue. In the graphs, the horizontal bar represents the mean and the error bars represent SEM. Asterisk indicates significantly different from Hilpda^flox/flox mice according to Tukey's posthoc test. ∗P < 0.05.