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Graphical depiction of the autocrine negative feedback regulation of triglyceride hydrolysis by fatty acids in adipocytes. Extracellular fatty acids upregulate Hilpda mRNA at least partly via FFAR4. Intracellular fatty acids upregulate HILPA protein at least partly by inducing ER stress and the PERK/eIF2α branch of the UPR pathway. Elevated HILPDA inhibits intracellular lipolysis by downregulating ATGL protein levels.
