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. 2023 Jun 7;26(7):107063. doi: 10.1016/j.isci.2023.107063

Figure 7.

Figure 7

Differential expression of appetite regulation genes at 72 hpf in glucose exposed or FFA/TAG injected embryos

(A) mRNA expression of genes in glucose exposed embryos compared to controls (Agouti-related Peptide (AgRP), Neuropeptide Y(NPY), Proopiomelanocortin (POMC), Cocaine- and Amphetamine-regulated Transcript (CART), Orexin, cannabinoid receptor type 1 (CB1), Corticotropin-releasing hormone (CRH), Oxytocin, Pituitary adenylate-cyclase activating peptide (PACAP 1A/1B), Steroidal factor-1 (SF-1).

(B) Expression of genes in FFA/TAG injected embryos compared to controls (Agouti-related Peptide (AgRP), Neuropeptide Y(NPY), Proopiomelanocortin (POMC), Cocaine- and Amphetamine-regulated Transcript (CART), Orexin, cannabinoid receptor type 1 (CB1), Corticotropin-releasing hormone (CRH), Oxytocin, Pituitary adenylate-cyclase activating peptide (PACAP 1A/1B), Steroidal factor 1 (SF-1).

(C) Compares mRNA expression in glucose exposed embryos and controls to the expression in embryos co-exposed to glucose and 3-Bromopyruvate in significant expressed appetite-regulating genes in Figure 7A.

(D) Compares mRNA expression in FFA/TAG injected embryos and controls to the expression in FFA/TAG embryos co-exposed to etomoxir in significant expressed appetite-regulating genes in Figure 7B. ∗ Represent statistically significant threshold levels (∗p < 0.05, ∗∗p < 0.01∗∗∗, p < 0.001,∗∗∗∗p < 0.0001).