Table 1.

Medications with proven CMR benefits and their respective targeted CMR abnormalities. CMR, cardio-metabolic-renal; T2D, type 2 diabetes; HF, heart failure; CKD, chronic kidney disease

	Metabolic targets	Cardiovascular targets	Renal targets
SGLT2i	• T2D [128, 132, 136] • Overweight [132, 136]	• Hypertension [132, 136] • HF [127, 134, 136] • CV death [128, 132]	• CKD [127, 131, 132, 142] • ESKD [127] • Albuminuria [132, 142]
GLP1 – RA	• T2D [126, 131] • Overweight/obesity [126, 131]	• Hypertension [126, 134, 137] • Atherosclerosis [131, 137] • Stroke [126, 134, 137] • CV death [131, 137]	• Albuminuria [126, 133, 134] • CKD? [131, 134]
Finerenone	• T2D (?) [129, 130]	• Hypertension [130] • HF [129, 130, 135]	• CKD [129, 135]
Tirzepatide	• T2D [138, 139] • Overweight/obesity [138, 139]	• CV risk factors [138, 143]	• Albuminuria? [144] • CKD? [144]