Table 2.

Current unmet needs and potential future directions to improve CMR management

Unmet needs	Future directions
Novel medications with CMR benefits	• Identification of druggable CMR connectors • Further efficacy and safety data of novel therapies
Combination therapy strategy	• Better understanding of drug mechanisms of action • Outcomes trials testing combination therapies
Integrated management of CMR disease	• Multidisciplinary approach
Risk-stratified personalized care	• Risk score validation for individualized prognostication • Clinical trials in specific populations (women/young/primary prevention)
Drug prioritization	• Head-to-head drug comparative trials

CMR, cardio-metabolic-renal