FIG. 1.

Effect of plasmid pCMV/VP1 vaccination on the clinical course of TMEV infection. pCMV/VP1 encodes TMEV capsid protein VP1. Two weeks after a single vaccination with vector pCMV (■) or pCMV/VP1 (○), SJL/J mice were injected intracerebrally with TMEV (day 0). Mice were monitored for weight change (a), righting reflex disturbance (b), and obvious clinical signs (c). Means ± standard errors are shown. Each experimental group consisted of three to five mice. pCMV/VP1-vaccinated mice showed less weight gain and more impaired righting reflex than control mice.