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. 2023 Jul 31;13:139. doi: 10.1186/s13578-023-01087-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — A higher proportion of LEFTY1 + epithelial subset cells and a lower proportion of epithelial subset cells in the G2/M phase were observed in OCCC samples than in HGSC samples. (A) UMAP plot displaying eight epithelial cell subpopulations. Each dot represents a single cell (n = 39,722). (B) The box plot shows the comparison of each epithelial cell percentage in the OCCC and HGSC groups. (C) Heatmap showing the average expression of the top 5 most highly expressed markers among epithelial cell subsets. (D) UMAP plot displaying the epithelial cell subsets in each cell cycle phase. (E) Heatmap showing regulon activity as analyzed by SCENIC. A “regulon” refers to the regulatory network of TFs and their target genes. “On” indicates active regulons; “Off” indicates inactive regulons. (F) Pseudotime reconstruction and development of epithelial cell subsets inferred from Monocle 3. (G) Pathway analysis of each epithelial cluster. P values were calculated by two-sided Wilcoxon test. *: p < 0.05, **: p < 0.01