Study ID	Intervention(s) and comparator(s)	Participants included in analysis (N)	Participants with at least one hypoglycaemic episode (N)	Participants with at least one hypoglycaemic episode (%)	Participants with at least one severe/serious hypoglycaemic episode (N)	Participants with at least one severe/serious hypoglycaemic episode (%)
Duncan 2018	I: hyperinsulinaemic normoglycaemia	226*	24*	10.6*	1*	0.4*
	C: standard therapy	249*	1*	0.4*	1*	0.4*
Wallia 2017	I: intensive (140)	23*	11*	47.8*	2*	8.7*
	C: moderate (180)	26*	1*	3.9*	0*	0*
Wahby 2016	I: tight glycaemic control	67	3	4.5	—	—
	C: conventional moderate glycaemic control	68	1	1.5	—	—
Parekh 2016	I: moderately intense control	30	0	0	0	0
	C: standard glucose control	30	0	0	0	0
Yuan 2015	I: intensive glycaemic management	106	—	—	8	7.5
	C: conventional glycaemic management	106	—	—	1	0.9
Umpierrez 2015	I: intensive group	77*	7*	9*	0*	0*
	C: conservative control	75*	4*	5*	0*	0*
Abdelmalak 2013	I: intensive glucose management	54*	0*	0*	1*	1.9*
	C: conventional glucose management	49*	0*	0*	0*	0*
Hermayer 2012	I: intensive glycaemic control	44	—	—	7	16
	C: standard glycaemic control	49	—	—	2	4
Desai 2012	I: strict blood glucose control	37*	18*	48,6*	1*	2.7*
	C: liberal blood glucose control	44*	15*	34.1*	0*	0*
Lazar 2011	I: aggressive glucose control	40	—	—	30	75
	C: moderate glucose control	42	—	—	4	9.52
Cao 2010	I: intensive insulin therapy	92	—	—	6	6.5
	C: conventional insulin therapy	87	—	—	1	1.1
Glucontrol 2009	I: intensive insulin treatment	55*	—	—	3*	5,5*
	C: intermediate glucose control	69*	—	—	1*	1.4*
NICE SUGAR 2009	I: intensive insulin therapy	213*	‐	‐	14*	6.6*
	C: conventional insulin therapy	208*	‐	‐	1*	0.5
Subramaniam 2009	I: continuous insulin infusion	62*	8*	12.9*	0*	0*
	C: standard intermittent sliding‐scale insulin bolus	64*	2*	3.1*	0*	0*
Chan 2009	I: intensive insulin therapy	10*	0*	0*	—	—
	C: conventional insulin therapy	22*	0*	0*	—	—
De La Rosa 2008	I: intensive insulin therapy	11*	—	—	0*	0*
	C: conventional insulin therapy	2*	—	—	1*	50*
Gandhi 2007	I: intensive insulin therapy	37	1	3	—	—
	C: conventional insulin therapy	36	6	16.6	—	—
Li 2006	I: continuous insulin infusion	51	—	—	—	—
	C: glucometer‐guided insulin	42	—	—	—	—
Lazar 2004	I: tight glycaemic control with GIK	72	—	—	—	—
	C: standard therapy	69	—	—	—	—
Rassias 1999	I: aggressive insulin therapy	13	—	—	—	—
	C: standard insulin therapy	13	—	—	—	—
—: denotes not reported *data provided by study authors (patients with diabetes). adata from total study population. C: comparator; I: intervention;GIK: glucose‐insulin‐potassium.