NCT02746432.

Methods	Type of study: interventional Allocation: randomised Type of trial: endpoint classification: efficacy study Intervention model: parallel assignment Masking: quadruple (participant, care provider, investigator, outcomes assessor) Primary purpose: treatment
Participants	Conditions: colorectal cancer Gender: both Age groups: adult/senior Enrolment: 144
Interventions	Intervention: hyper‐insulinaemic euglycaemic clamp Comparator: routine intraoperative saline infusion
Outcomes	Primary outcomes: the anti‐inflammatory effects of intraoperative hyper‐insulinaemic euglycaemic therapy in people undergoing colorectal cancer surgery (1 month); effect on inflammatory profile, namely levels of TNF‐alpha, IL‐8, IL‐6, IL‐10, IL‐1B, IL‐18, IFNy, MIp1‐alpha, MMP‐8, TGF‐beta, CRP Secondary outcomes: the immunomodulatory effect of intraoperative hyper‐insulinaemic euglycaemic infusion change (1 month) on CD4, CD8, T‐cell, quantity and activity
Reason for awaiting classification	Unknown
Study details	—
Official title and purpose of study	Insulin therapy reduce post‐operative inflammatory response after curative colorectal cancer resection: randomization controlled trial
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