Fig. 1.

KA alleviates DSS‐induced colitis via GPR35‐mediated sensing. (A) Schematic representation of the experimental design used. (B, C) The body weight (B) and disease activity score (C) of each rat were monitored daily, CID represents the GPR35 specificity inhibitor CID2745687. (D) The body weight and disease activity score were analyzed at the end of the experiment. (E) Western blot and quantification analyses of the ERK1/2 and p‐ERK1/2 protein expressions in the rat colon. (F) Intestinal permeability analysis. (G) H&E and AB staining analyses of the rat colon tissues, scale bars = 100 μm (as indicated). The data are presented as mean ± SD. Statistical analysis was performed using the Student's t test. n = 6, *P < 0.05, **P < 0.01 and ***P < 0.001.