Table 3.
Antiproliferative activities of compounds 16t–16y and colchicine.
Comp. |
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IC50 (μM)a |
||
---|---|---|---|---|
MGC-803 | HCT-116 | SMMC-7721 | ||
16t |
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5.87 ± 0.39b | 5.75 ± 0.42 | 6.82 ± 0.44 |
16u |
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7.55 ± 0.36 | 5.45 ± 0.42 | 7.12 ± 0.67 |
16v |
![]() |
6.37 ± 0.54 | 5.29 ± 0.38 | 8.16 ± 0.48 |
16w |
![]() |
5.48 ± 0.28 | 5.18 ± 0.41 | 6.11 ± 0.46 |
16x |
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5.13 ± 0.27 | 6.07 ± 0.16 | 5.12 ± 0.28 |
16y |
![]() |
5.18 ± 0.14 | 6.22 ± 0.28 | 5.01 ± 0.25 |
Colchicine | 0.066 ± 0.003 | 0.077 ± 0.002 | 0.087 ± 0.002 |
Cells were treated with different concentrations of compounds for 48 h to obtain the IC50 values. IC50 values are indicated as the mean ± SD of three independent experiments.