Table 3.
Receiver operating characteristic (ROC) analysis in gastric cancer patients for histological type, histological differentiation grade, depth of tumour invasion, presence of lymph node and distant metastasis.
| Parameter | AUC | p-value | Cut-off | Sensitivity (%) | Specificity (%) | 95% confidence interval |
|---|---|---|---|---|---|---|
| Histological type | ||||||
| AOPP (µmol/100 mg protein) | 0.7725 | 0.0050 | >15.23 | 73.33 | 69.57 | 0.5986-0.9463 |
| LOOH (nmol/100 mg protein) | 0.7022 | 0.0507 | <1304 | 63.64 | 65.52 | 0.5074-0.8970 |
| Histological differentiation grade | ||||||
| GPx (mU/100 mg protein) | 0.7067 | 0.0304 | >1.297 | 64.00 | 60.00 | 0.5442-0.8691 |
| TOS (µM/mg protein) | 0.7464 | 0.0181 | >12.46 | 65.22 | 66.67 | 0.5795-0.9133 |
| Total thiols (µM/mg protein) | 0.7279 | 0.0157 | >0.2152 | 75.00 | 75.00 | 0.5627-0.8930 |
| Depth of tumour invasion | ||||||
| SOD (mU/100 mg protein) | 0.7273 | 0.0373 | <2.806 | 66.67 | 63.64 | 0.5369-0.9177 |
| CAT (nmol H2O2/100 mg protein) | 0.7417 | 0.0370 | <125.0 | 77.78 | 60.00 | 0.5191-0.9642 |
| GPx (mU/100 mg protein) | 0.6997 | 0.0443 | <1.300 | 69.23 | 61.54 | 0.5165-0.8830 |
| TOS (µM/mg protein) | 0.7451 | 0.0185 | >6.735 | 75.00 | 72.73 | 0.5790-0.9112 |
| OSI (TOS/TAC ratio) | 0.7527 | 0.0079 | >0.211 | 65.22 | 62.50 | 0.5873-0.9181 |
| AOPP (µmol/100 mg protein) | 0.7284 | 0.0243 | >9.532 | 70.37 | 66.67 | 0.5707-0.8861 |
| Presence of lymph node metastasis | ||||||
| GR (µU/100 mg protein) | 0.7460 | 0.0247 | <18.60 | 70.0 | 68.00 | 0.5536-0.9384 |
| GSH (µg/100 mg protein) | 0.7619 | 0.0195 | <10.78 | 66.67 | 67.86 | 0.5792-0.9446 |
| TOS (µM/mg protein) | 0.7964 | 0.0059 | >6.735 | 75.0 | 80.00 | 0.6397-0.9532 |
| OSI (TOS/TAC ratio) | 0.7435 | 0.0192 | >0.509 | 72.73 | 75.00 | 0.5631-0.9239 |
| AOPP (µmol/100 mg protein) | 0.7341 | 0.0367 | >9.238 | 71.43 | 77.78 | 0.5709-0.8973 |
| Total thiols (µM/mg protein) | 0.7460 | 0.0282 | >0.211 | 67.86 | 66.67 | 0.5645-0.9276 |
| Presence of distant metastasis | ||||||
| SOD (mU/100 mg protein) | 0.7190 | 0.0430 | <2.349 | 63.64 | 63.64 | 0.5438-0.8942 |
| GSH (µg/100 mg protein) | 0.7106 | 0.0269 | <12.73 | 65.22 | 68.75 | 0.5436-0.8776 |
| TOS (µM/mg protein) | 0.7105 | 0.0246 | >15.83 | 63.16 | 65.00 | 0.5441-0.8769 |
| AOPP (µmol/100 mg protein) | 0.6889 | 0.0472 | >12.82 | 62.50 | 56.52 | 0.5136-0.8641 |
Abbreviations: SOD: superoxide dismutase-1, CAT: catalase; GPx: glutathione peroxidase; GR: glutathione reductase; GSH: reduced glutathione; TOS: total oxidant status; OSI: oxidative stress index; AOPP: advanced oxidation protein products; LOOH: lipid hydroperoxides.