Table 4.
Receiver operating characteristic (ROC) analysis in gastric cancer patients for type of GC according to Lauren and Goseki classifications and vascular and neural infiltration.
| Parameter | AUC | p-value | Cut-off | Sensitivity (%) | Specificity (%) | 95% confidence interval |
|---|---|---|---|---|---|---|
| Lauren classification | ||||||
| CAT (nmol H2O2/100 mg protein) | 0.7531 | 0.0328 | >97.22 | 68.75 | 70.00 | 0.5663-0.9399 |
| GR (µU/100 mg protein) | 0.7022 | 0.0476 | >18.60 | 70.59 | 68.75 | 0.5124-0.8921 |
| GPx (mU/100 mg protein) | 0.7135 | 0.0265 | >1.305 | 68.42 | 72.22 | 0.5352-0.8917 |
| GSH (µg/100 mg protein) | 0.6930 | 0.0449 | >12.69 | 63.16 | 61.11 | 0.5188-0.8672 |
| TAC (nmol/100 mg protein) | 0.7135 | 0.0265 | <3.524 | 68.42 | 66.67 | 0.5445-0.8824 |
| AOPP (µmol/100 mg protein) | 0.7032 | 0.0347 | >14.00 | 63.16 | 66.67 | 0.5271-0.8793 |
| Goseki classification | ||||||
| CAT (nmol H2O2/100 mg protein) | 0.7827 | 0.0043 | >69.44 | 70.59 | 61.11 | 0.6327-0.9327 |
| GSH (µg/100 mg protein) | 0.7255 | 0.0277 | >11.21 | 72.73 | 69.23 | 0.5365-0.9147 |
| Total thiols (µM/mg protein) | 0.7561 | 0.0090 | >21.77 | 68.18 | 66.67 | 0.6009-0.9113 |
| Vascular infiltration | ||||||
| GR (µU/100 mg protein) | 0.8933 | 0.0054 | >14.87 | 80.0 | 80.00 | 0.7824-1.000 |
| GPx (mU/100 mg protein) | 0.8000 | 0.0339 | >1.291 | 80.0 | 80.00 | 0.5390-1.000 |
| GSH (µg/100 mg protein) | 0.9853 | 0.0017 | >7.213 | 94.12 | 100.0 | 0.9491-1.000 |
| Neural infiltration | ||||||
| GSH (µg/100 mg protein) | 0.9875 | 0.0005 | >7.213 | 96.88 | 100.0 | 0.9569-1.000 |
Abbreviations: CAT: catalase; GPx: glutathione peroxidase; GR: glutathione reductase; GSH: reduced glutathione; TAC: total antioxidant capacity; AOPP: advanced oxidation protein products.