FIG. 1.

Test viruses. Reporter viruses used to test for the induction of inflammation are presented schematically. The viruses are isogenic except for the pTP gene. (Top) The first-generation, replication-defective virus Ad5dl308β-gal (43) chromosome is presented as a thick line, and early-region transcription units are indicated by arrows. The splicing pattern for pTP is indicated by the broken lines above the chromosome. The region of deletion or replacement within E3 (19) is indicated by the thick line in the enlargement below the chromosome. The regions encoding pTP and DNA polymerase (DNA pol) are indicated below the chromosome. (Bottom) Ad5dl308_ΔpTPβ-gal is presented as for Ad5dl308β-gal; the regions deleted from the pTP gene are indicated by the thick lines in the enlargements below the chromosome.