Table 4.

Details of case reports of inoperable, metastatic or recurrent MTC treated with radioactive iodine (¹³¹I)

Reference	Sites of Disease	Activity of Iodine Administered (GBq)	Sites of Iodine Uptake after Therapy Dose or Prior Tracer Dose	Response on Subsequent Iodine Scans	Calcitonin before Iodine (pg/ml)	Calcitonin after Iodine (pg/ml)	Symptomatic Response
35	inoperable (thyroid and bilateral neck)	1.85, 3.7, 3.7	ns	ns		reduced by 63% (actual values not given)	diarrhoea resolved after second dose
35	inoperable (thyroid, neck and mediastinum); metastasis in femur	3.7, 4.6, 4.6, 3.7, 3.7	thyroid left femur		19,420	8,650	pain and dyspnoea resolved; diarrhoea resolved after first dose
34	neck, bones	3.7, 4.14, 7.4	neck, bones and “internal”	regression in size of lesions	ns	ns	less pain
36	lungs, choroidal metastases	11.9	lungs		250,000	235,000	vision improved after 2 days; dyspnoea and diarrhoea improved
35	neck, lungs	ns	ns			no response	none
32	lungs	two doses (activity not stated)	ns			no response	none
37	neck and anterior mediastinum	tracer only	neck and anterior mediastinum			not applicable: tracer only	not applicable: tracer only
35	none identified	3.7, 3.7	none		141,000	67,800	no diarrhoea after 4 days
35	neck	1.85, 3.7	neck	disappearance of uptake in neck	31,900	16,380
35	neck	1.85, 2.8	neck	disappearance of uptake in neck	220,400	31,500
33	neck	tracer	none			not applicable: tracer only	not applicable: tracer only
33 *	neck	single dose (activity not stated)	none			raised; no response
summary of responses			6/12			reduced by > 48% in 5/9	5/10

ns, not stated.

^aalso received ¹³¹I as adjuvant therapy (Table 3).