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(a) Schematic representation of specific protein–DNA contacts exploited by the four residues motif (RRxYD) of E2F1-DP1 in different systems. (b) Cartoon representation of the binding orientations and DNA contacts of the E2F1-DP1 dimer for WT (blue) and ME (orange) systems, when bound alone to DNA (solo) and together with CEBPB (complex).
