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. 2023 Jul 18;15:1220036. doi: 10.3389/fnagi.2023.1220036

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Copyright © 2023 Jullienne, Szu, Quan, Trinh, Norouzi, Noarbe, Bedwell, Eldridge, Persohn, Territo and Obenaus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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5xFAD mice exhibit increased vascular leakage consistent with blood–brain barrier (BBB) disruption. Representative confocal image of DiI extravasation areas (blue arrows) in an 8-month-old 5xFAD male (A). The proportion of mice with BBB disruptions increased with time in 5xFAD mice relative to WT (B) with females having a consistent increasing leak trajectory. Leak area was compiled (C) and revealed a maximal increase in leak area at 8 months followed by a reduction at 12 months in 5xFAD mice. For multiple comparisons between genotypes and across time (non-parametric Kruskal–Wallis test): **p < 0.01.