TABLE 3.

Summary of the results as change in 5xFAD mice compared to WT.

	All mice					Males					Females
	4 months	6–8 months	12 months	Age effect?	Genotype effect?	4 months	6–8 months	12 months	Age effect?	Genotype effect?	4 months	6–8 months	12 months	Age effect?	Genotype effect?
Cerebrum volume		↓		↑					↑			↓		↑
Cortical vessel density				↑					↑
Cortical junction density				↑					↑
Cortical total vessel length				↑					↑
Cortical average vessel length				↑					↑
MCA vessel density									↑
MCA junction density	↓			↑		↓			↑
MCA total vessel length	↓			↑		↓			↑
MCA average vessel length	↓	↓
Number of DiI extravasations		↑		↑			↑							↑
Collateral number				↓					↓					↓
Collateral diameter		↓		↓↑		↓			↓↑			↓		↓↑
FDG-FrA
FDG-Cg				↓↑
FDG-M2								↑
FDG-M1				↓↑					↓↑
FDG-S1				↓↑					↓↑
FDG-S2				↓↑					↓↑			↓		↓↑
FDG-RSC				↓				↑	↓
FDG-V1/V2		↓						↑					↓
FDG-total cortex				↓↑					↓↑
Volume-FrA				↑				↓						↑
Volume-Cg		↑		↑					↑
Volume-M1/M2				↓↑				↓	↓↑					↑
Volume-S1/S2		↑		↓					↓			↑	↑
Volume-RSC		↑		↓			↑		↓
Volume-V1/V2
Volume-total cortex		↑					↑					↑	↑